Article
The impact of costimulatory molecule gene polymorphisms on clinical outcomes in liver transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Apr 2003
Marder Brad A, Schröppel Bernd, Lin Marvin, Schiano Thomas, Parekh Rulan, Tomer Yaron, Murphy Barbara
Abstract excerpt
CTLA-4 and CD28 deliver opposing signals for T-cell proliferation. We examined single nucleotide polymorphisms (SNPs) CTLA-4 -318C/T and CD28 IVS3 +17T/C for associations with acute rejection in liver transplant recipients. These and two other polymorphisms in CTLA-4 [microsatellite polymorphism...
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