Article
Macrophage phenotype in the subclinical gut inflammation of patients with ankylosing spondylitis.
Rheumatology (Oxford, England) - 1 Jan 2014
Ciccia Francesco, Alessandro Riccardo, Rizzo Aroldo, Accardo-Palumbo Antonina, Raimondo Stefania, Raiata Francesca, Guggino Giuliana, Giardina AnnaRita, De Leo Giacomo, Sireci Guido, Triolo Giovanni
Abstract excerpt
OBJECTIVE: Long-term evolution of subclinical gut inflammation to overt Crohn's disease (CD) has been described in AS patients. The aim of this study was to evaluate macrophage polarization occurring in the inflamed gut of patients with AS. METHODS: Twenty-seven HLA-B27(+) AS patients, 20 CD patients and 17 normal controls were consecutively enrolled. Classic M1 (iNOS(+)IL-10(-)), resolution phase...
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