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Predicting genome-wide tissue-specific enhancers via combinatorial transcription factor genomic occupancy analysis.

FEBS letters - 1 Jan 2025

Shireen Huma, Batool Fatima, Khatoon Hizran, Parveen Nazia, Sehar Noor Us, Hussain Irfan, Ali Shahid, Abbasi Amir Ali

Abstract excerpt

Enhancers are non-coding cis-regulatory elements crucial for transcriptional regulation. Mutations in enhancers can disrupt gene regulation, leading to disease phenotypes. Identifying enhancers and their tissue-specific activity is challenging due to their lack of stereotyped sequences. This study presents a sequence-based computational model that uses combinatorial transcription factor (TF) genomic occupancy to...

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PMID: 39367524
DOI: 10.1002/1873-3468.15030

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