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Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens

29 Jan 2020

Abstract excerpt

Abstract Purpose: The purpose of this study was to evaluate antigen experienced T cells in peripheral blood lymphocytes (PBL) for responses to p53 neoantigens. Experimental Design: PBLs from patients with a mutated TP53 tumor were sorted for antigen-experienced T cells and in vitro stimulation (IVS) was performed with p53 neoantigens. The IVS cultures were stimulated with antigen-presenting cells expressing p53...

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PMID: 31996390
DOI: 10.1158/1078-0432.ccr-19-1874

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