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Paper-supported 3D cell culture for tissue-based bioassays

21 Oct 2009

Abstract excerpt

Fundamental investigations of human biology, and the development of therapeutics, commonly rely on 2D cell-culture systems that do not accurately recapitulate the structure, function, or physiology of living tissues. Systems for 3D cultures exist but do not replicate the spatial distributions of oxygen, metabolites, and signaling molecules found in tissues. Microfabrication can create architecturally complex...

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PMID: 19846768
DOI: 10.1073/pnas.0910666106

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