Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Three‐dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

1 Sept 2014

Abstract excerpt

Cancers are complex and heterogeneous pathological "organs" in a dynamic interplay with their host. Models of human cancer in vitro, used in cancer biology and drug discovery, are generally highly reductionist. These cancer models do not incorporate complexity or heterogeneity. This raises the question as to whether the cancer models' biochemical circuitry (not their genome) represents, with sufficient fidelity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to Cancer Cells and Metastasis
Share to Cellular Mechanics and Interactions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25174503
DOI: 10.1002/biot.201300492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three‐dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivoPMID 25174503Read ↗

Breaking the mold: 3D cell cultures reshaping the future of cancer researchSemantic proximity Read ↗

Ex Vivo Tumor Culture Systems for Functional Drug Testing and Therapy Response PredictionSemantic proximity Read ↗

Three-dimensional in vitro culture models in oncology researchSemantic proximity Read ↗

Three-Dimensional Organoids in Cancer Research: The Search for the Holy Grail of Preclinical Cancer ModelingSemantic proximity Read ↗

Contributions of 3D Cell Cultures for Cancer Research.Semantic proximity Read ↗

3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer DrugsSemantic proximity Read ↗

Organoids: Past Learning and Future DirectionsSemantic proximity Read ↗

Emerging Strategies in 3D Culture Models for Hematological CancersSemantic proximity Read ↗

Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo modelsSemantic proximity Read ↗

From 2D Drug Screening to Predictive Pharmacology: Redefining Preclinical Models in OncologySemantic proximity Read ↗

In Vitro 3D Cultures to Model the Tumor MicroenvironmentSemantic proximity Read ↗

Non-Animal Models for Studying the Effects of Chemotherapeutic Drugs on Breast Cancer MetastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.