Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression

24 Sept 2012

Abstract excerpt

Slug (Snail2) plays critical roles in regulating the epithelial-mesenchymal transition (EMT) programs operative during development and disease. However, the means by which Slug activity is controlled remain unclear. Herein we identify an unrecognized canonical Wnt/GSK3β/β-Trcp1 axis that controls Slug activity. In the absence of Wnt signaling, Slug is phosphorylated by GSK3β and subsequently undergoes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23011797
DOI: 10.1073/pnas.1205822109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repressionPMID 23011797Read ↗

SLUG: Critical regulator of epithelial cell identity in breast development and cancerSemantic proximity Read ↗

Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breastSemantic proximity Read ↗

EMT associated transcription factors Slug and Snail demonstrate specific expression patterns in breast cancer subtypes, involving tumor or stroma components and correlating with proliferation status and complex clinical prognosisSemantic proximity Read ↗

BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer.Semantic proximity Read ↗

Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast CancerSemantic proximity Read ↗

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.Semantic proximity Read ↗

Targeting the WNT/beta-catenin/TCF/LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options.Semantic proximity Read ↗

The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer.Semantic proximity Read ↗

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.Semantic proximity Read ↗

Cross-talk of WNT and FGF signaling pathways at GSK3ß to regulate ß-catenin and SNAIL signaling cascadesSemantic proximity Read ↗

Non-canonical functions of SNAIL drive context-specific cancer progressionSemantic proximity Read ↗

Snail and Slug Promote Epithelial-Mesenchymal Transition through β-Catenin–T-Cell Factor-4-dependent Expression of Transforming Growth Factor-β3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.