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Article

A binding free energy decomposition approach for accurate calculations of the fidelity of DNA polymerases.

Proteins - 15 Feb 2010

Rucker Robert, Oelschlaeger Peter, Warshel Arieh

Abstract excerpt

DNA polymerase beta (pol beta) is a small eukaryotic enzyme with the ability to repair short single-stranded DNA gaps that has found use as a model system for larger replicative DNA polymerases. For all DNA polymerases, the factors determining their catalytic power and fidelity are the interactions between the bases of the base pair, amino acids near the active site, and the two magnesium ions. In this report, we...

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Identifiers

PMID: 19842163
DOI: 10.1002/prot.22596
PMCID: PMC2966340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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