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Article

Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway.

Journal of the American Chemical Society - 20 Jun 2012

Li Yunlang, Gridley Chelsea L, Jaeger Joachim, Sweasy Joann B, Schlick Tamar

Abstract excerpt

Mutations in DNA polymerase β (pol β) have been associated with approximately 30% of human tumors. The E295K mutation of pol β has been linked to gastric carcinoma via interference with base excision repair. To interpret the different behavior of E295K as compared to wild-type pol β in atomic and energetic detail, we resolve a binary crystal complex of E295K at 2.5 Å and apply transition path sampling (TPS) to...

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Identifiers

PMID: 22651551
DOI: 10.1021/ja300361r
PMCID: PMC3383778

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Source receipt: pubmed, retrieved 7 Sept 2026.

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