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Article

Targeting Müller Cell–Derived VEGF<sub>164</sub>to Reduce Intravitreal Neovascularization in the Rat Model of Retinopathy of Prematurity

15 Jan 2014

Abstract excerpt

PURPOSE: To determine whether knockdown of Müller cell-derived VEGFA-splice variant, VEGF164, which is upregulated in the rat retinopathy of prematurity (ROP) model, safely inhibits intravitreal neovascularization (IVNV). METHODS: Short hairpin RNAs for VEGF164 (VEGF164.shRNAs) or luciferase.shRNA control were cloned into lentivectors with CD44 promoters that specifically target Müller cells. Knockdown...

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PMID: 24425851
DOI: 10.1167/iovs.13-13755

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