Article

Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium

2021-11-08

Abstract excerpt

<h4>ABSTRACT</h4> Anti-TNF antibodies are effective for treating patients with inflammatory bowel disease (IBD), but many patients fail to respond to anti-TNF therapy, highlighting the importance of TNF-independent disease. We previously demonstrated that acute deletion of two IBD susceptibility genes, A20 ( Tnfaip3 ) and Abin-1 ( Tnip1 ), in intestinal epithelial cells (IECs) sensitizes mice to both TNF-depe...

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Literature Corpus work: a63afaea-4693-5d56-b0c4-c06e7738d174
DOI: 10.1101/2021.11.08.467808

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