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Article

Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres.

Cell research - 1 May 2013

Gu Peili, Deng Wei, Lei Ming, Chang Sandy

Abstract excerpt

Human single-strand (ss) DNA binding proteins 1 and 2 (hSSB1 and 2) are components of the hSSB1/2-INTS3-C9orf80 heterotrimeric protein complex shown to participate in DNA damage response and maintenance of genome stability. However, their roles at telomeres remain unknown. Here, we generated murine SSB1 conditional knockout mice and cells and found that mSSB1 plays a critical role in telomere end protection. Both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23459151
DOI: 10.1038/cr.2013.31
PMCID: PMC3641597

Genes

INTS3

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