Article
Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets.
BMC genetics - 25 Feb 2013
Ho Maggie M, Yoganathan Piriya, Chu Kwan Yi, Karunakaran Subashini, Johnson James D, Clee Susanne M
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have recently identified many new genetic variants associated with the development of type 2 diabetes. Many of these variants are in introns of known genes or between known genes, suggesting they affect the expression of these genes. The regulation of gene expression is often tissue and context dependent, for example occurring in response to dietary changes,...
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