Rapid Modification of Proteins Using a Rapamycin-Inducible Tobacco Etch Virus Protease System

Abstract excerpt

BACKGROUND: The ability to disrupt the function of a specific protein on a rapid time scale provides a powerful tool for biomedical research. Specific proteases provide a potential method to selectively cleave a chosen protein, but rapid control of protease activity is difficult. METHODOLOGY/PRINCIPAL FINDINGS: A heterologous expression system for rapid target-directed proteolysis in mammalian cells was...

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