Article
Basic mechanisms of neurodegeneration: a critical update
11 Jan 2010
Abstract excerpt
Abstract Introduction Protein aggregation Oxidative injury Impaired bioenergetics and mitochondrial dysfunction Fragmentation of neuronal Golgi apparatus Disruption of cellular/axonal transport Dysfunction of neurotrophins ‘Neuroinflammatory’ processes The final pathway: multifaceted neuronal death Cell death cascades in major NDDs Acknowledgements Neurodegenerative diseases are characterized by progressive...
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