Article
Molecular determinant-based typing of KIR alleles and KIR ligands.
Clinical immunology (Orlando, Fla.) - 1 Mar 2011
Bari Rafijul, Leung Matthias, Turner Victoria E, Embrey Christy, Rooney Barbara, Holladay Martha, Leung Wing
Abstract excerpt
Killer cell immunoglobulin-like receptors (KIRs) regulate NK cell function. KIRs and their HLA ligands are highly polymorphic in nature with substantial allelic polymorphism. At present, there is a lack of an expedient method for KIR and HLA allele typing with relevant functional information. Here, we developed a single-nucleotide polymorphism (SNP) assay to type various allele groups of KIR2DL1 with distinct...
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