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Article

Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions.

Genes, chromosomes & cancer - 1 Jan 2010

Anzick Sarah L, Chen Wei-Dong, Park Yoonsoo, Meltzer Paul, Bell Diana, El-Naggar Adel K, Kaye Frederic J

Abstract excerpt

The CRTC1-MAML2 fusion oncogene underlies the etiology of mucoepidermoid salivary gland carcinoma (MEC) where it confers a favorable survival outcome as compared with fusion-negative MEC. While these analyses suggested that detection of CRTC1-MAML2 serves as a useful prognostic biomarker, we recently identified outlier cases of fusion-positive MEC associated with advanced-staged lethal disease. To identify...

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Source

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Identifiers

PMID: 19827123
DOI: 10.1002/gcc.20719
PMCID: PMC2783528

Genes

CRTC1
MAML2
EGFR
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions.PMID 19827123Read ↗

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