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Article

HER2 and EGFR gene copy number alterations are predominant in high-grade salivary mucoepidermoid carcinoma irrespective of MAML2 fusion status.

Histopathology - 1 Sept 2013

Nakano Takafumi, Yamamoto Hidetaka, Hashimoto Kazuki, Tamiya Sadafumi, Shiratsuchi Hideki, Nakashima Torahiko, Nishiyama Ken-ichi, Higaki Yuichiro, Komune Shizuo, Oda Yoshinao

Abstract excerpt

AIMS: In this study, we aimed to investigate the molecular mechanisms underlying the development of mucoepidermoid carcinoma (MEC). METHODS AND RESULTS: In 31 cases, we examined the MAML2 fusion status using reverse transcriptase-polymerase chain reaction, and HER2 and EGFR status using immunohistochemistry and chromogenic in-situ hybridization. MAML2 fusions were detected in 15 (57.7%) of 26 MECs analysed,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23855785
DOI: 10.1111/his.12183

Genes

MAML2
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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