Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.

Current opinion in chemical biology - 1 Dec 2009

Wagner Bridget K, Clemons Paul A

Abstract excerpt

Discovering small-molecule modulators for thousands of gene products requires multiple stages of biological testing, specificity evaluation, and chemical optimization. Many cellular profiling methods, including cellular sensitivity, gene expression, and cellular imaging, have emerged as methods to assess the functional consequences of biological perturbations. Cellular profiling methods applied to small-molecule...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells
Share to Chemistry
Share to Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Proteomics

Share to Small Molecule Libraries

Source

Open in PubMed Open full text

Identifiers

PMID: 19825513
DOI: 10.1016/j.cbpa.2009.09.018
PMCID: PMC2787914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.PMID 19825513Read ↗

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds.Semantic proximity Read ↗

Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Semantic proximity Read ↗

Small Molecule Probes of Cellular Pathways and NetworksSemantic proximity Read ↗

Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Semantic proximity Read ↗

QMAP-Seq: Quantitative and Multiplexed Analysis of Phenotype by SequencingSemantic proximity Read ↗

Design of phenotypic screens for bioactive chemicals and identification of their targets by genetic and proteomic approaches.Semantic proximity Read ↗

Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq.Semantic proximity Read ↗

From Phenotypic Hit to Chemical Probe: Chemical Biology Approaches to Elucidate Small Molecule Action in Complex Biological Systems.Semantic proximity Read ↗

Complex phenotypic assays in high-throughput screening.Semantic proximity Read ↗

Combining label-free cell phenotypic profiling with computational approaches for novel drug discovery.Semantic proximity Read ↗

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.Semantic proximity Read ↗

Combined Analysis of Phenotypic and Target-Based Screening in Assay Networks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.