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Article

Complex phenotypic assays in high-throughput screening.

Current opinion in chemical biology - 1 Jun 2004

Clemons Paul A

Abstract excerpt

High-throughput screening (HTS), systematically testing thousands of small molecules to find candidates for lead optimization, primarily involves exposure of purified proteins to arrayed collections of small molecules. More complex phenotypic assays, such as cell-based or whole-organism assays, traditionally have flanked HTS, preceding it to validate new therapeutic targets, and following it to characterize new...

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Identifiers

PMID: 15183333
DOI: 10.1016/j.cbpa.2004.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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