Article
The Association of KRAS and P53 Gene Mutations and MDM2 Expression with the Occurrence of Colorectal Cancer.
Current cancer drug targets - 1 Jan 2026
Al-Hussaniy Hany A, Oraibi Amjad I, Al-Tameemi Zahraa Salam, Alburghaif Ali Hikmat, Naji Meena Akeel, Naji Fatima Akeel
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) encompasses various cancers located in the rectosigmoid junction, rectum, and anus, as well as parts of the colon. Globally, CRC is the second leading cause of cancer-related mortality and the third most prevalent malignancy. The KRAS oncogene was found to be mutated in 30 to 50% of CRC cases, leading to dysregulated cellular functions. Furthermore, the connection between KRAS...
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- Humans
- Colorectal Neoplasms
- Proto-Oncogene Proteins c-mdm2
- Mutation
- Proto-Oncogene Proteins p21(ras)
- Tumor Suppressor Protein p53