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Article

Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability.

Epilepsia - 1 Jan 2010

Thomas Evan A, Reid Christopher A, Petrou Steven

Abstract excerpt

PURPOSE: Idiopathic epilepsy is caused by the complex interaction of genetic and environmental factors. The purpose of this study was to use computational approaches to explore the interaction between changes in sodium channel availability caused by mutations and mossy fiber sprouting. METHODS: We used a previously published biophysically realistic computer model of dentate gyrus neurons and networks. A...

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Source

Identifiers

PMID: 19682031
DOI: 10.1111/j.1528-1167.2009.02202.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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