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Article

Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits.

Neuroscience - 29 Jul 2007

Thomas E A, Xu R, Petrou S

Abstract excerpt

Mutations in Na+ channels cause a variety of epilepsy syndromes. Analysis of these mutations shows a range of simultaneous functional consequences, each of which may increase or decrease membrane excitability, making it difficult to predict the combined effect on neuron firing. This may be addressed by building mathematical models of Na+ channel gating and using them in neuron models to predict responses to...

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PMID: 17604911
DOI: 10.1016/j.neuroscience.2007.05.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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