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Article

Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions.

Nature neuroscience - 1 Nov 2009

Kurshan Peri T, Oztan Asli, Schwarz Thomas L

Abstract excerpt

Synaptogenesis involves the transformation of a growth cone into synaptic boutons specialized for transmitter release. In Drosophila embryos lacking the alpha(2)delta-3 subunit of presynaptic, voltage-dependent Ca(2+) channels, we found that motor neuron terminals failed to develop synaptic boutons and cytoskeletal abnormalities arose, including the loss of ankyrin2. Nevertheless, functional presynaptic...

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Identifiers

PMID: 19820706
DOI: 10.1038/nn.2417
PMCID: PMC2996863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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