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Article

Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted mice.

The Journal of clinical investigation - 1 Mar 2000

Uren D, Hwang H K, Hara Y, Takeda K, Kawamoto S, Tullio A N, Yu Z X, Ferrans V J, Tresser N, Grinberg A, Preston Y A, Adelstein R S

Abstract excerpt

Complete ablation of nonmuscle myosin heavy chain II-B (NMHC-B) in mice resulted in cardiac and brain defects that were lethal during embryonic development or on the day of birth. In this paper, we report on the generation of mice with decreased amounts of NMHC-B. First, we generated B(DeltaI)/B(DeltaI) mice by replacing a neural-specific alternative exon with the PGK-Neo cassette. This resulted in decreased...

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Identifiers

PMID: 10712438
DOI: 10.1172/JCI8199
PMCID: PMC289177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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