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Article

Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata.

Journal of lipid research - 1 Apr 2012

Kanzawa Noriyuki, Shimozawa Nobuyuki, Wanders Ronald J A, Ikeda Kazutaka, Murakami Yoshiko, Waterham Hans R, Mukai Satoru, Fujita Morihisa, Maeda Yusuke, Taguchi Ryo, Fujiki Yukio, Kinoshita Taroh

Abstract excerpt

Many cell surface proteins in mammalian cells are anchored to the plasma membrane via glycosylphosphatidylinositol (GPI). The predominant form of mammalian GPI contains 1-alkyl-2-acyl phosphatidylinositol (PI), which is generated by lipid remodeling from diacyl PI. The conversion of diacyl PI to 1-alkyl-2-acyl PI occurs in the ER at the third intermediate in the GPI biosynthetic pathway. This lipid remodeling...

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Source

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Identifiers

PMID: 22253471
DOI: 10.1194/jlr.M021204
PMCID: PMC3307642

Genes

GPI
PEX16
PEX19
PEX5
PEX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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