Article
Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum.
Molecular biology of the cell - 1 May 2008
Kajiwara Kentaro, Watanabe Reika, Pichler Harald, Ihara Kensuke, Murakami Suguru, Riezman Howard, Funato Kouichi
Abstract excerpt
Glycosylphosphatidylinositol (GPI), covalently attached to many eukaryotic proteins, not only acts as a membrane anchor but is also thought to be a sorting signal for GPI-anchored proteins that are associated with sphingolipid and sterol-enriched domains. GPI anchors contain a core structure conserved among all species. The core structure is synthesized in two topologically distinct stages on the leaflets of the...
Topics
- Acetylglucosamine
- Biological Transport
- Ceramides
- Depsipeptides
- Endoplasmic Reticulum
- Genes, Fungal
- Glycosphingolipids
- Glycosylphosphatidylinositols
- Golgi Apparatus
- Intracellular Space
- Lipid Metabolism
- Mannose