Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new model of LMP1-MYC interaction in B cell lymphoma.

Leukemia & lymphoma - 1 Dec 2014

Ontiveros Evelena P, Halwani Ahmad, Stunz Laura L, Kamberos Natalie, Olivier Alicia K, Janz Siegfried, Bishop Gail A

Abstract excerpt

Epstein-Barr virus (EBV) is associated with aggressive B cell lymphomas (BCLs). Latent membrane protein 1 (LMP1) of EBV is an oncogenic protein required for EBV B cell transformation. However, LMP1 is a weak oncogene in mice. Mice expressing Myc inserted 5' of the Eμ enhancer (iMyc(Eμ)), mimicking the t(8;14) translocation of endemic Burkitt lymphoma, develop delayed onset BCLs. To investigate potential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphoma, B-Cell
Share to Mice, Transgenic
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Immunophenotyping

Share to Interleukin-6

Share to Proto-Oncogene Proteins c-myc

Share to Viral Matrix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24605938
DOI: 10.3109/10428194.2014.900762
PMCID: PMC4207734

Genes

MYC
CD40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new model of LMP1-MYC interaction in B cell lymphoma.PMID 24605938Read ↗

Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis.Semantic proximity Read ↗

Latent membrane proteins from EBV differentially target cellular pathways to accelerate MYC-induced lymphomagenesisSemantic proximity Read ↗

LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.Semantic proximity Read ↗

Epstein-Barr virus in Burkitt’s lymphoma: A role for latent membrane protein 2ASemantic proximity Read ↗

Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in miceSemantic proximity Read ↗

A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.Semantic proximity Read ↗

Mouse model of Epstein–Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative diseaseSemantic proximity Read ↗

Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not EssentialSemantic proximity Read ↗

Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice.Semantic proximity Read ↗

Utilization of Pathway Signatures to Reveal Distinct Types of B Lymphoma in the Eμ- myc Model and Human Diffuse Large B-Cell LymphomaSemantic proximity Read ↗

Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.Semantic proximity Read ↗

Epstein-Barr Virus LMP2A-Induced B-Cell Survival in Two Unique Classes of EμLMP2A Transgenic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.