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Article

Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation.

The Journal of biological chemistry - 4 Dec 2009

Tuli Amit, Sharma Mahak, Capek Haley L, Naslavsky Naava, Caplan Steve, Solheim Joyce C

Abstract excerpt

Earlier studies have demonstrated interaction of the murine major histocompatibility complex (MHC) class I molecule K(d) with amyloid precursor-like protein 2 (APLP2), a ubiquitously expressed member of the amyloid precursor protein family. Our current findings indicate that APLP2 is internalized in a clathrin-dependent manner, as shown by utilization of inhibitors of the clathrin pathway. Furthermore, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19808674
DOI: 10.1074/jbc.M109.039727
PMCID: PMC2797198

Genes

APLP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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