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Article

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.

The Journal of cell biology - 5 Oct 2009

Lamkanfi Mohamed, Mueller James L, Vitari Alberto C, Misaghi Shahram, Fedorova Anna, Deshayes Kurt, Lee Wyne P, Hoffman Hal M, Dixit Vishva M

Abstract excerpt

Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1beta (IL-1beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns (DAMPs), and crystals. Inappropriate Cryopyrin activity has been incriminated in the pathogenesis of gouty arthritis, Alzheimer's, and silicosis. Therefore,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19805629
DOI: 10.1083/jcb.200903124
PMCID: PMC2762099

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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