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Article

Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal.

The Journal of biological chemistry - 27 Nov 2009

Noorwez Syed M, Sama Reddy Ranjith K, Kaushal Shalesh

Abstract excerpt

The lectin chaperone calnexin (Cnx) is important for quality control of glycoproteins, and the chances of correct folding of a protein increase the longer the protein interacts with Cnx. Mutations in glycoproteins increase their association with Cnx, and these mutant proteins are retained in the endoplasmic reticulum. However, until now, the increased interaction with Cnx was not known to increase the folding of...

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Identifiers

PMID: 19801547
DOI: 10.1074/jbc.M109.043364
PMCID: PMC2785176

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