Article
Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H.
The Journal of biological chemistry - 16 Apr 2004
Noorwez Syed M, Malhotra Ritu, McDowell J Hugh, Smith Karen A, Krebs Mark P, Kaushal Shalesh
Abstract excerpt
The clinically common mutant opsin P23H, associated with autosomal dominant retinitis pigmentosa, yields low levels of rhodopsin when retinal is added following induction of the protein in stably transfected HEK-293 cells. We previously showed that P23H rhodopsin levels could be increased by providing a 7-membered ring, locked analog of 11-cis-retinal during expression of P23H opsin in vivo. Here we demonstrate...
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