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Article

A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis.

Journal of medicinal food - 1 Oct 2010

Markert Chad D, Kim Eunkuk, Gifondorwa David J, Childers Martin K, Milligan Carol E

Abstract excerpt

The underlying causes of denervation of the neuromuscular junction and eventual motor neuron death in amyotrophic lateral sclerosis (ALS) have not been resolved. The superoxide dismutase 1 (SOD1)(G93A) mutant mouse is a frequently used animal model of ALS. We hypothesized that resveratrol (RSV), a polyphenolic molecule that enhances mammalian NAD(+)-dependent SIRT1 deacetylases and may increase life span, would...

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Source

Identifiers

PMID: 20626250
DOI: 10.1089/jmf.2009.0243

Genes

SIRT1
SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis.PMID 20626250Read ↗

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