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Article

LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice

30 Sept 2019

Abstract excerpt

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons. Improving neuronal survival in ALS remains a significant challenge. Previously, we identified Lanthionine synthetase C-like protein 1 (LanCL1) as a neuronal antioxidant defense gene, the genetic deletion of which causes apoptotic neurodegeneration in the brain. Here, we report in...

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PMID: 31570855
DOI: 10.1038/s41418-019-0422-6

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