Article
IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Nov 2009
Martinelli Giovanni, Iacobucci Ilaria, Storlazzi Clelia Tiziana, Vignetti Marco, Paoloni Francesca, Cilloni Daniela, Soverini Simona, Vitale Antonella, Chiaretti Sabina, Cimino Giuseppe, Papayannidis Cristina, Paolini Stefania, Elia Loredana, Fazi Paola, Meloni Giovanna, Amadori Sergio, Saglio Giuseppe, Pane Fabrizio, Baccarani Michele, Foà Robin
Abstract excerpt
PURPOSE: The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia (ALL) are unknown. To identify, at the submicroscopic level, oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed an investigation of genomic copy number alterations using single nucleotide polymorphism array, genomic polymerase chain reaction, and sequencing of candidate genes. PATIENTS AND...
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