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Article

Origin and functional consequences of the complex I defect in Parkinson's disease

1 Oct 1996

Abstract excerpt

The mitochondrial electron transport enzyme NADH:ubiquinone oxidoreductase (complex I), which is encoded by both mitochondrial DNA and nuclear DNA, is defective in multiple tissues in persons with Parkinson's disease (PD). The origin of this lesion and its role in the neurodegeneration of PD are unknown. To address these questions, we created an in vitro system in which the potential contributions of...

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Identifiers

PMID: 8871587
DOI: 10.1002/ana.410400417

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