Article
Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.
Diabetes - 1 Jan 2010
Lango Allen Hana, Johansson Stefan, Ellard Sian, Shields Beverley, Hertel Jens K, Raeder Helge, Colclough Kevin, Molven Anders, Frayling Timothy M, Njølstad Pål R, Hattersley Andrew T, Weedon Michael N
Abstract excerpt
OBJECTIVE: Mutations in the HNF1A gene are the most common cause of maturity-onset diabetes of the young (MODY). There is a substantial variation in the age at diabetes diagnosis, even within families where diabetes is caused by the same mutation. We investigated the hypothesis that common polyge...
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