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Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.

Diabetes - 1 Jun 2008

Holmkvist Johan, Almgren Peter, Lyssenko Valeriya, Lindgren Cecilia M, Eriksson Karl-Fredrik, Isomaa Bo, Tuomi Tiinamaija, Nilsson Peter, Groop Leif

Abstract excerpt

OBJECTIVE: Mutations in the hepatocyte nuclear factor (HNF)-1alpha, HNF-4alpha, glucokinase (GCK), and HNF-1beta genes cause maturity-onset diabetes of the young (MODY), but it is not known whether common variants in these genes predict future type 2 diabetes. RESEARCH DESIGN AND METHODS: We tested 14 previously associated polymorphisms in HNF-1alpha, HNF-4alpha, GCK, and HNF-1beta for association with type 2...

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Identifiers

PMID: 18332101
DOI: 10.2337/db06-1464

Genes

GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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