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The Common HNF1A Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY.

Diabetes - 1 Sept 2018

Locke Jonathan M, Saint-Martin Cécile, Laver Thomas W, Patel Kashyap A, Wood Andrew R, Sharp Seth A, Ellard Sian, Bellanné-Chantelot Christine, Hattersley Andrew T, Harries Lorna W, Weedon Michael N

Abstract excerpt

There is wide variation in the age at diagnosis of diabetes in individuals with maturity-onset diabetes of the young (MODY) due to a mutation in the HNF1A gene. We hypothesized that common variants at the HNF1A locus (rs1169288 [I27L], rs1800574 [A98V]), which are associated with type 2 diabetes susceptibility, may modify age at diabetes diagnosis in individuals with HNF1A-MODY. Meta-analysis of two independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29895593
DOI: 10.2337/db18-0133
PMCID: PMC6109380

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