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Determinants of the development of diabetes (maturity-onset diabetes of the young-3) in carriers of HNF-1alpha mutations: evidence for parent-of-origin effect.

Diabetes care - 1 Dec 2002

Klupa Tomasz, Warram James H, Antonellis Anthony, Pezzolesi Marcus, Nam Moonsuk, Malecki Maciej T, Doria Alessandro, Rich Stephen S, Krolewski Andrzej S

Abstract excerpt

OBJECTIVE: To determine the distribution of the age at onset of diabetes (maturity-onset diabetes of the young-3 [MODY3]) and to identify determinants of the onset of diabetes in carriers of HNF-1alpha mutations. RESEARCH DESIGN AND METHODS: Extended families (n = 104) with type 2 diabetes inherited in a dominant pattern were recruited and screened for diabetes-causing mutations in HNF-1alpha. RESULTS: HNF-1alpha...

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PMID: 12453976
DOI: 10.2337/diacare.25.12.2292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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