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Article

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

29 Sept 2009

Abstract excerpt

Mutations affecting the conversion of PI3P to the signaling lipid PI(3,5)P(2) result in spongiform degeneration of mouse brain and are associated with the human disorders Charcot-Marie-Tooth disease and amyotrophic lateral sclerosis (ALS). We now report accumulation of the proteins LC3-II, p62 and LAMP-2 in neurons and astrocytes of mice with mutations in two components of the PI(3,5)P(2) regulatory complex, Fig4...

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Identifiers

PMID: 19793721
DOI: 10.1093/hmg/ddp460

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