Article
Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor-negative juvenile chronic arthritis.
Rheumatology international - 1 Jan 1993
Brunner H I, Ivaskova E, Haas J P, Andreas A, Keller E, Hoza J, Havelka S, Scholz S, Sierp G, Albert E D
Abstract excerpt
A total of 94 patients with juvenile chronic arthritis (JCA) was tested for HLA class I by serology and for class II by RFLP typing. Early onset JCA (EOPA) is associated with HLA-A2, DR5 and DR8 in both males and females. The combination (joint occurrence) of these JCA associated alleles (A2, DR5...
Topics
- Adolescent
- Alleles
- Arthritis, Juvenile
- Child
- Child, Preschool
- DNA
- Female
- Gene Frequency
- Genotype
- HLA-A Antigens
- HLA-B Antigens
- HLA-B27 Antigen
- HLA-DR Antigens
- Histocompatibility Antigens Class I
- Humans