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Article

HLA-DQA1*0101 haplotypes and disease outcome in early onset pauciarticular juvenile rheumatoid arthritis.

The Journal of rheumatology - 1 Jun 1991

van Kerckhove C, Luyrink L, Taylor J, Melin-Aldana H, Balakrishnan K, Maksymowych W, Elma M, Lovell D, Choi E, Glass D N

Abstract excerpt

To further investigate a clinical impression that patients with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) who carry HLA-DQw1 have more severe arthritis, we subtyped HLA-DQw1 in American midwestern patients with EOPA-JRA. The HLA-DQA1*0101 subtype was present in 10 of 19 patients who developed persistent polyarticular erosive disease compared with 18 of 92 healthy controls (chi 2 = 9.13,...

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PMID: 1680192

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