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A Cohort Study of Cyclin D1 Expression and Prognosis in 602 Colon Cancer Cases

23 Jun 2009

Abstract excerpt

PURPOSE: Cyclin D1 and cyclin-dependent kinases (CDK) are commonly activated in colorectal cancer. The activity of cyclin D1 can be blocked by CDK inhibitors, including p27 (CDKN1B) and p21 (CDKN1A, which is induced by p53). However, prognostic significance of tumoral cyclin D1 remains uncertain, and no previous study has considered potential confounding effect of p53, p21, p27, and related molecular events...

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PMID: 19549773
DOI: 10.1158/1078-0432.ccr-08-3330

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