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Article

Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway.

Cancer letters - 28 Jan 2015

Xu Wei, Wang Ziwei, Zhang Wei, Qian Kun, Li Hui, Kong Dequan, Li Yuqiang, Tang Yucheng

Abstract excerpt

Cyclin-dependent kinase 8 (CDK8), a gene encoding the cyclin-dependent kinase (CDK) component of the Mediator complex, is known as a colon cancer oncogene. Our recent study showed that CDK8 plays an important role in the formation of pancreatic cancer, but the CDK8 expression levels were not completely identical in different pancreatic cancer samples. The level of CDK8 expression depended on whether the K-ras...

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Source

Identifiers

PMID: 25305448
DOI: 10.1016/j.canlet.2014.10.008

Genes

CDK8
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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