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Article

Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer.

Cancer research - 1 Apr 2010

Paliwal Anupam, Vaissière Thomas, Krais Annette, Cuenin Cyrille, Cros Marie-Pierre, Zaridze David, Moukeria Anush, Boffetta Paolo, Hainaut Pierre, Brennan Paul, Herceg Zdenko

Abstract excerpt

Nicotinic acetylcholine receptor (nAChR) genes form a highly conserved gene cluster at the lung cancer susceptibility locus 15q25.1. In this study, we show that the CHRNalpha3 gene encoding the nAChRalpha3 subunit is a frequent target of aberrant DNA hypermethylation and silencing in lung cancer, whereas the adjacent CHRNbeta4 and CHRNalpha5 genes exhibit moderate and no methylation, respectively. Treatment of...

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Identifiers

PMID: 20332232
DOI: 10.1158/0008-5472.CAN-09-4550
PMCID: PMC2856323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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