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Article

Oncogenic BRAF and the tumor suppressor IGFBP7 in the genesis of atypical spitzoid nevomelanocytic proliferations.

Journal of cutaneous pathology - 1 Mar 2010

Emley Andrew, Yang Shi, Wajapeyee Narendra, Green Michael R, Mahalingam Meera

Abstract excerpt

Rare reports indicate that the frequency of BRAFV600E mutations is high in atypical Spitz nevi. The purpose of this study was to ascertain the utility of the RAF/RAS mutational status as a diagnostic adjunct in lesions with histologic features that deviate from a typical Spitz nevus and, to examine expression of Insulin growth factor binding protein 7 (IGFBP7), a tumor suppressor acting through...

Read the complete abstract on PubMed

Topics

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Share to Cell Proliferation
Share to Diagnosis, Differential

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Immunohistochemistry

Share to Insulin-Like Growth Factor Binding Proteins

Share to Melanoma

Share to Proto-Oncogene Proteins B-raf

Share to Skin Neoplasms

Source

Identifiers

PMID: 19788444
DOI: 10.1111/j.1600-0560.2009.01433.x

Genes

BRAF
IGFBP7
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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