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Article

Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis

25 Sept 2009

Abstract excerpt

Recent studies suggest that histone deacetylase (HDAC) inhibitors may therapeutically prevent cartilage degradation in osteoarthritis (OA). Matrix metalloproteinase-13 (MMP-13) plays an important role in the pathogenesis of this disease and in the present study we investigated the correlation between HDACs and MMP-13. Comparing the expression of different HDACs in cartilage from OA patients and healthy donors,...

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PMID: 19784544
DOI: 10.1007/s10165-009-0224-7

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