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DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

4 Aug 2017

Abstract excerpt

The Runt-related transcription factor 2 (RUNX2) is critical for bone formation as well as chondrocyte maturation. Matrix metalloproteinase (MMP)-13 is a major contributor to cartilage degradation in osteoarthritis (OA). We and others have shown that the abnormal MMP13 gene expression in OA chondrocytes is controlled by changes in the DNA methylation status of specific CpG sites of the proximal promoter, as well...

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PMID: 28798419
DOI: 10.1038/s41598-017-08418-8

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