Article
A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Feb 2010
Martin Rosalind J L, McKnight Amy J, Patterson Christopher C, Sadlier Denise M, Maxwell Alexander P
Abstract excerpt
BACKGROUND: Vitamin D and its analogues are reported to have renoprotective effects in chronic kidney disease including diabetic nephropathy (DN). Vitamin D(3) is converted to 1,25(OH)D(3) by CYP2R1 and CYP27B1. The biological action of 1,25(OH)D(3) is mediated via its receptor. VDR, CYP27B1 or C...
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